This study describes the temporal changes in risk profiles and outcomes among patients with aortic stenosis (AS) undergoing surgical aortic valve replacement (SAVR) in Australia between 2002 and 2015.Using the Australian and New Zealand Society of Cardiac and Thoracic Surgeons database, we identified first-recorded SAVR for AS over 14 years.
Patients’ surgical risk profiles, procedures, 30-day and 12-month outcomes were summarized before and after the introduction of transcatheter aortic valve implantation in Australia, in 2008.
We applied multivariable regression models to investigate the changes over time on risk-adjusted 30-day mortality, re-hospitalization and 12-month mortality.We identify a total of 18 147 patients with AS who underwent SAVR; mostly men (64%) with a mean age of 72 years.
The proportion of major cardiac surgeries devoted to SAVR increased from 14% in 2002 to 20% in 2015. More SAVRs were performed electively (80% in 2002 versus 86% in 2015), and the recipients were at lower surgical risk (mean multi-risk score 3.9% in 2002 versus 3.0% in 2015).
4-ArmPEG-SAA,10K |
33-A44015-10K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
4-ArmPEG-SAA,20K |
33-A44015-20K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
4-ArmPEG-SAA,2K |
33-A44015-2K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
Bovine Serum Amyloid A (SAA) ELISA Kit |
DLR-SAA-b-48T |
DL Develop |
48T |
EUR 547 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Serum Amyloid A (SAA) in samples from serum, plasma or other biological fluids. |
Bovine Serum Amyloid A (SAA) ELISA Kit |
DLR-SAA-b-96T |
DL Develop |
96T |
EUR 715 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Serum Amyloid A (SAA) in samples from serum, plasma or other biological fluids. |
Human Serum Amyloid A (SAA) ELISA Kit |
DLR-SAA-Hu-48T |
DL Develop |
48T |
EUR 479 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Human Serum Amyloid A (SAA) ELISA Kit |
DLR-SAA-Hu-96T |
DL Develop |
96T |
EUR 621 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Mouse Serum Amyloid A (SAA) ELISA Kit |
DLR-SAA-Mu-48T |
DL Develop |
48T |
EUR 489 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Mouse Serum Amyloid A (SAA) ELISA Kit |
DLR-SAA-Mu-96T |
DL Develop |
96T |
EUR 635 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Rabbit Serum Amyloid A (SAA) ELISA Kit |
DLR-SAA-Rb-48T |
DL Develop |
48T |
EUR 508 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Rabbit Serum Amyloid A (SAA) ELISA Kit |
DLR-SAA-Rb-96T |
DL Develop |
96T |
EUR 661 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Serum Amyloid A (SAA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Bovine Serum Amyloid A (SAA) ELISA Kit |
RDR-SAA-b-48Tests |
Reddot Biotech |
48 Tests |
EUR 580 |
Bovine Serum Amyloid A (SAA) ELISA Kit |
RDR-SAA-b-96Tests |
Reddot Biotech |
96 Tests |
EUR 807 |
Human Serum Amyloid A (SAA) ELISA Kit |
RDR-SAA-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 500 |
Human Serum Amyloid A (SAA) ELISA Kit |
RDR-SAA-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 692 |
Mouse Serum Amyloid A (SAA) ELISA Kit |
RDR-SAA-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 511 |
Mouse Serum Amyloid A (SAA) ELISA Kit |
RDR-SAA-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 709 |
Rabbit Serum Amyloid A (SAA) ELISA Kit |
RDR-SAA-Rb-48Tests |
Reddot Biotech |
48 Tests |
EUR 534 |
Rabbit Serum Amyloid A (SAA) ELISA Kit |
RDR-SAA-Rb-96Tests |
Reddot Biotech |
96 Tests |
EUR 742 |
Bovine Serum Amyloid A (SAA) ELISA Kit |
RD-SAA-b-48Tests |
Reddot Biotech |
48 Tests |
EUR 555 |
Bovine Serum Amyloid A (SAA) ELISA Kit |
RD-SAA-b-96Tests |
Reddot Biotech |
96 Tests |
EUR 771 |
Human Serum Amyloid A (SAA) ELISA Kit |
RD-SAA-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 478 |
Human Serum Amyloid A (SAA) ELISA Kit |
RD-SAA-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 662 |
Mouse Serum Amyloid A (SAA) ELISA Kit |
RD-SAA-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 489 |
Mouse Serum Amyloid A (SAA) ELISA Kit |
RD-SAA-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 677 |
Rabbit Serum Amyloid A (SAA) ELISA Kit |
RD-SAA-Rb-48Tests |
Reddot Biotech |
48 Tests |
EUR 511 |
Rabbit Serum Amyloid A (SAA) ELISA Kit |
RD-SAA-Rb-96Tests |
Reddot Biotech |
96 Tests |
EUR 709 |
TruStrip RDT Human Serum Amyloid A (SAA) Rapid Test cards, 10 tests/pack |
SAA-RDT-10 |
Alpha Diagnostics |
1 pack |
EUR 171 |
TruStrip RDT Human Serum Amyloid A (SAA) Rapid Test cards, 25 tests/pack |
SAA-RDT-25 |
Alpha Diagnostics |
1 pack |
EUR 293 |
SAA-PEG-SAA |
abx085047-10kDa1g |
Abbexa |
10 kDa; 1 g |
EUR 453 |
|
SAA-PEG-SAA |
abx085047-1kDa1g |
Abbexa |
1 kDa; 1 g |
EUR 453 |
|
SAA-PEG-SAA |
abx085047-20kDa1g |
Abbexa |
20 kDa; 1 g |
EUR 453 |
|
SAA-PEG-SAA |
abx085047-2kDa1g |
Abbexa |
2 kDa; 1 g |
EUR 453 |
|
SAA-PEG-SAA,10K |
33-HO015015-10K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SAA-PEG-SAA,1K |
33-HO015015-1K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SAA-PEG-SAA,20K |
33-HO015015-20K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SAA-PEG-SAA,2K |
33-HO015015-2K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SAA-PEG-SAA,3.4K |
33-HO015015-3.4K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SAA-PEG-SAA,5K |
33-HO015015-5K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
IL-4 Interleukin 4 Human Recombinant Protein, Yeast |
PROTP05112-4 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: Interleukin-4 Human Recombinant produced in yeast is a single, glycosylated polypeptide chain containing 129 amino acids.;The IL-4 is purified by proprietary chromatographic techniques. |
Individual Reaction Mix 4 |
G065-4 |
ABM |
200 reactions |
EUR 167 |
SAA Protein |
abx060299-100ug |
Abbexa |
100 ug |
EUR 829 |
|
mPEG-SAA |
abx085023-10kDa1g |
Abbexa |
10 kDa; 1 g |
EUR 370 |
|
mPEG-SAA |
abx085023-1kDa1g |
Abbexa |
1 kDa; 1 g |
EUR 356 |
|
mPEG-SAA |
abx085023-20kDa1g |
Abbexa |
20 kDa; 1 g |
EUR 370 |
|
mPEG-SAA |
abx085023-2kDa1g |
Abbexa |
2 kDa; 1 g |
EUR 356 |
|
mPEG-SAA |
abx085023-5kDa1g |
Abbexa |
5 kDa; 1 g |
EUR 356 |
|
SAA antibody |
10-7959 |
Fitzgerald |
500 ug |
EUR 349 |
Description: Mouse monoclonal SAA antibody |
SAA antibody |
10-7960 |
Fitzgerald |
500 ug |
EUR 349 |
Description: Mouse monoclonal SAA antibody |
SAA antibody |
10R-10351 |
Fitzgerald |
100 ug |
EUR 435 |
Description: Mouse monoclonal SAA antibody |
SAA antibody |
20-1715 |
Fitzgerald |
1 ml |
EUR 138 |
Description: Goat polyclonal SAA antibody |
Feline IL-4 Recombinant Protein |
R00230-4 |
BosterBio |
5ug/vial |
EUR 259 |
Description: IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Feline IL-4 Recombinant Protein is purified interleukin-4 produced in yeast. |
Recombinant Human PF-4 (CXCL4) Protein |
PROTP02776-4 |
BosterBio |
20ug |
EUR 317 |
Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines. |
Mouse FibrOut 4, for brain, neural |
4-20507 |
CHI Scientific |
1 ml |
Ask for price |
Mouse FibrOut 4, for brain, neural |
4-20508 |
CHI Scientific |
5 x 1 ml |
Ask for price |
Rat FibrOut 4, for brain, neural |
4-20533 |
CHI Scientific |
1 ml |
Ask for price |
Rat FibrOut 4, for brain, neural |
4-20534 |
CHI Scientific |
5 x 1 ml |
Ask for price |
Human FibrOut 4, for brain, neural |
4-21552 |
CHI Scientific |
1 ml |
Ask for price |
Human FibrOut 4, for brain, neural |
4-21553 |
CHI Scientific |
5 x 1 ml |
Ask for price |
DIGITAL SHAKER FOR 4 MICROPLATES, 120V |
6780-4 |
CORNING |
1/pk |
EUR 798 |
Description: Lab Equipment; Shakers & Mixers |
Recombinant Human 4-1BB Receptor Protein |
PROTQ07011-4 |
BosterBio |
20ug |
EUR 317 |
Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor. |
Bone Dissociation System 4 (Osteoblasts), Adult Mouse |
4-20214 |
CHI Scientific |
ea |
Ask for price |
Liver Dissociation System 4 (Hepatocytes, rat), Rat |
4-20304 |
CHI Scientific |
ea |
Ask for price |
Pituitary Dissociation System 4 (Pituitary), Adult mouse |
4-20404 |
CHI Scientific |
ea |
Ask for price |
Thymus Dissociation System 4 (Epithelial), Adult rat |
4-20444 |
CHI Scientific |
ea |
Ask for price |
mPEG-SAA,10K |
33-MF001015-10K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
mPEG-SAA,1K |
33-MF001015-1K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
mPEG-SAA,20K |
33-MF001015-20K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
mPEG-SAA,2K |
33-MF001015-2K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
mPEG-SAA,30K |
33-MF001015-30K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
mPEG-SAA,4K |
33-MF001015-4K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
mPEG-SAA,5K |
33-MF001015-5K |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
Recombinant Human SAA |
P0209 |
FN Test |
100ug |
EUR 522.36 |
|
Description: Recombinant Human protein for SAA |
Apo SAA antibody |
20R-1792 |
Fitzgerald |
100 ug |
EUR 673 |
Description: Rabbit polyclonal Apo SAA antibody |
Cartilage Dissociation System 4 (Chondrocytes), Mouse and Rat |
4-20234 |
CHI Scientific |
ea |
Ask for price |
Mammary Dissociation System 4 (Epithelial, Swiss 3T3), Mouse |
4-20324 |
CHI Scientific |
ea |
Ask for price |
Pancreas Dissociation System 4 (Islets), Mouse and Rat |
4-20374 |
CHI Scientific |
ea |
Ask for price |
Skin Dissociation System 4 (Keratinocytes), Mouse and Rat |
4-20434 |
CHI Scientific |
ea |
Ask for price |
DIGITAL SHAKER FOR 4 MICROPLATES, 230V-EU PLUG |
6781-4 |
CORNING |
1/pk |
EUR 798 |
Description: Lab Equipment; Shakers & Mixers |
DIGITAL SHAKER FOR 4 MICROPLATES, 230V-UK PLUG |
6782-4 |
CORNING |
1/pk |
EUR 798 |
Description: Lab Equipment; Shakers & Mixers |
Adipose/Fat Dissociation System 4 (Predipocytes), Mouse and Rat |
4-20194 |
CHI Scientific |
ea |
Ask for price |
Brain Dissociation System 4 (Endothelial, Microvessels), Mouse and Rat |
4-20224 |
CHI Scientific |
ea |
Ask for price |
Endothelial Dissociation System 4 (Endothelial,Cerebral), Mouse and Rat |
4-20244 |
CHI Scientific |
ea |
Ask for price |
Heart Dissociation System 4 (Myocytes,Ventricles), Mouse and Rat |
4-20274 |
CHI Scientific |
ea |
Ask for price |
Muscle Dissociation System 4 (Smooth muscle), Mouse and Rat |
4-20334 |
CHI Scientific |
ea |
Ask for price |
Parotid Dissociation System 4 (Parotid acinar), Mouse and Rat |
4-20394 |
CHI Scientific |
ea |
Ask for price |
Epithelial Dissociation System 4 (Epithelial,Submandibular salivary), Mouse and Rat |
4-20254 |
CHI Scientific |
ea |
Ask for price |
Heart Dissociation System 4 (Retinal pigment epithelial), Mouse and Rat |
4-20294 |
CHI Scientific |
ea |
Ask for price |
Lung Dissociation System 4 (Alveolar type II), Mouse and Rat |
4-20314 |
CHI Scientific |
ea |
Ask for price |
Reproductive Tissue Dissociation System 4 (Epithelial, vagina), Mouse and Rat |
4-20414 |
CHI Scientific |
ea |
Ask for price |
ExoStd? Lyophilized Exosome Standard (30 µg, Human Plasma, 4 vials) |
M1040-4 |
Biovision |
|
EUR 909 |
ExoStd? Lyophilized Exosome Standard (100 µg, Human Plasma, 4 vials) |
M1041-4 |
Biovision |
|
EUR 1137 |
ExoStd? Lyophilized Exosome Standard (30 µg, Human Serum, 4 vials) |
M1042-4 |
Biovision |
|
EUR 909 |
The use of bioprosthetic aortic valves increased over time (67% in 2002 to 88% in 2015). We found no significant changes in 30-day mortality, a significant decrease in 30-day readmission and minor fluctuations in 12-month mortality over the study period.SAVR comprises an increasingly larger proportion of all adult cardiac surgeries in Australia. There has been a greater use of bioprosthetic aortic valves, a fall in 30-day readmission but no significant changes in mortality.